Which theory describes aging as due to cross-linked proteins from glucose binding to proteins?

Which theory describes aging as due to cross-linked proteins from glucose binding to proteins?

• A. Cross-link
• B. Wear-and-tear
• C. Free radical
• D. Programmed longevity

Answer: (A)

Cross-link theory explains aging as the result of glucose binding to proteins, creating cross-links that stiffen tissues. When proteins like collagen form these cross-links, skin loses elasticity and blood vessels become less flexible, contributing to wrinkles and vascular rigidity. The resulting advanced glycation end products accumulate with age and are amplified by high blood glucose, connecting aging processes with diabetes-related tissue changes. Other theories describe aging as wear-and-tear from use, damage from free radicals, or programmed genetic timing, but the scenario described specifically points to cross-linking of proteins by glucose.

Cross-link theory explains aging as the result of glucose binding to proteins, creating cross-links that stiffen tissues. When proteins like collagen form these cross-links, skin loses elasticity and blood vessels become less flexible, contributing to wrinkles and vascular rigidity. The resulting advanced glycation end products accumulate with age and are amplified by high blood glucose, connecting aging processes with diabetes-related tissue changes. Other theories describe aging as wear-and-tear from use, damage from free radicals, or programmed genetic timing, but the scenario described specifically points to cross-linking of proteins by glucose.